PKAcb.docx
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PKAcb.docx
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PKAcb
>NM_001164198
Comment
∙Features
∙Sequence
LOCUSNM_0011641984337bpmRNAlinearROD26-FEB-2014DEFINITIONMusmusculusproteinkinase,cAMPdependent,catalytic,beta(Prkacb),transcriptvariant2,mRNA.ACCESSIONNM_001164198VERSIONNM_001164198.1GI:
255958317KEYWORDSRefSeq.SOURCEMusmusculus(housemouse)ORGANISMMusmusculusEukaryota;Metazoa;Chordata;Craniata;Vertebrata;Euteleostomi;Mammalia;Eutheria;Euarchontoglires;Glires;Rodentia;Sciurognathi;Muroidea;Muridae;Murinae;Mus;Mus.REFERENCE1(bases1to4337)AUTHORSMamenkoM,ZaikaOL,BoukelmouneN,BerroutJ,O'NeilRGandPochynyukO.TITLEDiscretecontrolofTRPV4channelfunctioninthedistalnephronbyproteinkinasesAandCJOURNALJ.Biol.Chem.288(28),20306-20314(2013)PUBMED23709216REMARKGeneRIF:
DataindicatethatTRPV4activityandTRPV4traffickingareunderdiscretebutsynergisticcontrolofPKC-andPKA-dependentpathways.REFERENCE2(bases1to4337)AUTHORSGarcia-HaroL,Garcia-GimenoMA,NeumannD,BeullensM,BollenMandSanzP.TITLEGlucose-dependentregulationofAMP-activatedproteinkinaseinMIN6betacellsisnotaffectedbytheproteinkinaseApathwayJOURNALFEBSLett.586(23),4241-4247(2012)PUBMED23116618REFERENCE3(bases1to4337)AUTHORSBandayAR,AzimSandTabishM.TITLEIdentificationandexpressionanalysisofthreenovelsplicevariantsofproteinkinaseAcatalyticbetasubunitgeneinthemouseusingcombinatorialinsilicoandmolecularbiologyapproachesJOURNALFEBSJ.279(4),572-585(2012)PUBMED22151102REMARKGeneRIF:
StudiesidentifiedthreenovelalternativelysplicedtranscriptvariantsofthemouseproteinkinaseAcatalyticbetasubunit(Cbeta)genedesignatedCbeta5,Cbeta6andCbeta7.REFERENCE4(bases1to4337)AUTHORSTusonM,HeMandAndersonKV.TITLEProteinkinaseAactsatthebasalbodyoftheprimaryciliumtopreventGli2activationandventralizationofthemouseneuraltubeJOURNALDevelopment138(22),4921-4930(2011)PUBMED22007132REFERENCE5(bases1to4337)AUTHORSYinZ,PringleDR,JonesGN,KellyKMandKirschnerLS.TITLEDifferentialroleofPKAcatalyticsubunitsinmediatingphenotypescausedbyknockoutoftheCarneycomplexgenePrkar1aJOURNALMol.Endocrinol.25(10),1786-1793(2011)PUBMED21852354REMARKGeneRIF:
ThesedatasuggestthatbothdevelopmentalandtumorphenotypescausedbyPrkar1amutationresultfromexcessPKAactivityduetoPKA-Ca.REFERENCE6(bases1to4337)AUTHORSBrandonEP,ZhuoM,HuangYY,QiM,GerholdKA,BurtonKA,KandelER,McKnightGSandIdzerdaRL.TITLEHippocampallong-termdepressionanddepotentiationaredefectiveinmicecarryingatargeteddisruptionofthegeneencodingtheRIbetasubunitofcAMP-dependentproteinkinaseJOURNALProc.Natl.Acad.Sci.U.S.A.92(19),8851-8855(1995)PUBMED7568030REFERENCE7(bases1to4337)AUTHORSCummingsDE,EdelhoffS,DistecheCMandMcKnightGS.TITLECloningofamouseproteinkinaseAcatalyticsubunitpseudogeneandchromosomalmappingofCsubunitisoformsJOURNALMamm.Genome5(11),701-706(1994)PUBMED7873880REFERENCE8(bases1to4337)AUTHORSBeebeSJ,OyenO,SandbergM,FroysaA,HanssonVandJahnsenT.TITLEMolecularcloningofatissue-specificproteinkinase(Cgamma)fromhumantestis--representingathirdisoformforthecatalyticsubunitofcAMP-dependentproteinkinaseJOURNALMol.Endocrinol.4(3),465-475(1990)PUBMED2342480REFERENCE9(bases1to4337)AUTHORSChriviaJC,UhlerMDandMcKnightGS.TITLECharacterizationofgenomicclonescodingfortheCalphaandCbetasubunitsofmousecAMP-dependentproteinkinaseJOURNALJ.Biol.Chem.263(12),5739-5744(1988)PUBMED2833513REFERENCE10(bases1to4337)AUTHORSUhler,M.D.,Chrivia,J.C.andMcKnight,G.S.TITLEEvidenceforasecondisoformofthecatalyticsubunitofcAMP-dependentproteinkinaseJOURNALJ.Biol.Chem.261(33),15360-15363(1986)PUBMED3023318REMARKErratum:
[JBiolChem1987Apr15;262(11):
5431]COMMENTVALIDATEDREFSEQ:
Thisrecordhasundergonevalidationorpreliminaryreview.ThereferencesequencewasderivedfromCB723114.1,AK139419.1andBC054533.1.TranscriptVariant:
Thisvariant
(2)usesanalternativeexonatthe5'endcomparedtovariant1.Theresultingisoform
(2)hasadistinctandshorterN-terminus,ascomparedtoisoform1.PublicationNote:
ThisRefSeqrecordincludesasubsetofthepublicationsthatareavailableforthisgene.PleaseseetheGenerecordtoaccessadditionalpublications.##Evidence-Data-START##Transcriptexoncombination:
:
AK139419.1[ECO:
0000332]RNAseqintrons:
:
mixed/partialsamplesupportSRS307248,SRS307249[ECO:
0000350]##Evidence-Data-END##COMPLETENESS:
completeonthe3'end.PRIMARYREFSEQ_SPANPRIMARY_IDENTIFIERPRIMARY_SPANCOMP1-257CB723114.11-257258-4038AK139419.13-37834039-4337BC054533.14027-4325FEATURESLocation/Qualifierssource1..4337/organism="Musmusculus"/mol_type="mRNA"/strain="C57BL/6"/db_xref="taxon:
10090"/chromosome="3"/map="3"gene1..4337gene:
基因/gene="Prkacb"/gene_synonym="Pkacb"/note="proteinkinase,cAMPdependent,catalytic,beta"/db_xref="GeneID:
18749"/db_xref="MGI:
MGI:
97594"exon1..305exon:
外显子/gene="Prkacb"/gene_synonym="Pkacb"/inference="alignment:
Splign:
1.39.8"misc_feature236..238misc_feature:
不能用任何其它的特征关键词表述的具有生物学意义的区域;新的或少见的特征。
/gene="Prkacb"/gene_synonym="Pkacb"/note="upstreamin-framestopcodon"CDS299..1315CDS:
cds(codingsequence),指的是cDNA上蛋白质编码序列,与ORF(开放阅读框)的概念差不多,只是cds不包括终止密码子,而ORF包括终止密码子在内。
/gene="Prkacb"/gene_synonym="Pkacb"/EC_number="2.7.11.11"/note="isoform2isencodedbytranscriptvariant2;cAMP-dependentproteinkinasecatalyticsubunitbeta;PKAC-beta;cAMP-dependentproteinkinaseCbeta"/codon_start=1/product="cAMP-dependentproteinkinasecatalyticsubunitbetaisoform2"/protein_id="NP_001157670.1"/db_xref="GI:
255958318"/db_xref="CCDS:
CCDS51090.1"/db_xref="GeneID:
18749"/db_xref="MGI:
MGI:
97594"/translation="MNVKEFLAKAKEDFLRKWENPPPSNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVEFPFLVRLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEEEIRVSITEKCGKEFCEF"misc_feature383..1252
exon一词包括编码区即codingexon和3‘UTR和5'UTR三部分。
而codingexon仅指编码CDS的部分外显子。
/gene="Prkacb"/gene_synonym="Pkacb"/note="CatalyticdomainoftheProteinSerine/ThreonineKinase,cAMP-dependentproteinkinase;Region:
STKc_PKA;cd05580"/db_xref="CDD:
173671"misc_feature353..1312/gene="Prkacb"/gene_synonym="Pkacb"/note="proteinkinaseAcatalyticsubunit;Provisional;Region:
PTZ00263"/db_xref="CDD:
140289"misc_featureorder(410..427,431..433,470..472,476..478,506..508,572..574,620..625,629..631,641..643,647..649,659..661,758..760,764..775,779..781,809..814,821..823,854..856,860..871,950..952,962..970,977..985,989..991,998..1000,1241..1243,1250..1252)/gene="Prkacb"/gene_synonym="Pkacb"/note="activesite"/db_xref="CDD:
173671"misc_featureorder(407..427,431..433,470..472,476..478,572..574,620..631,641..643,758..760,764..766,770..775,779..781,809..814,1241..1243)/gene="Prkacb"/gene_synonym="Pkacb"/note="ATPbindingsite[chemicalbinding];othersite"/db_xref="CDD:
173671"misc_featureorder(413..415,419..424,506..514,641..643,647..649,659..661,758..760,764..772,821..823,854..871,950..952,962..970,977..985,989..991,998..1003,1250..1252)/gene="Prkacb"/gene_synonym="Pkacb"/note="substratebindingsite[chemicalbinding];othersite"/db_xref="CDD:
173671"misc_feature809..871/gene="Prkacb"/gene_synonym="Pkacb"/note="activationloop(A-loop);othersite"/db_xref="CDD:
173671"misc_featureorder(413..415,419..421,509..514,518..523,641..643,647..649,659..661,758..760,764..772,821..823,842..844,848..874,890..898,950..952,968..970,977..979,989..994,1001..1006,1013..1015,1250..1252)/gene="Prkacb"/gene_synonym="Pkacb"/note="catalyticsubunit/regulatorysubunitinterface[polypeptidebinding];othersite"/db_xref="CDD:
173671"exon306..367/gene="Prkacb"/gene_synonym="Pkacb"/inference="alignment:
Splign:
1.39.8"exon368..496/gene="Prkacb"/gene_synonym="Pkacb"/inference="alignment:
Splign:
1.39.8"exon497..595/gene="Prkacb"/gene_synonym="Pkacb"/inference="alignment:
Splign:
1.39.8"exon596..678/gene="Prkacb"/gene_synonym="Pkacb"/inference="alignment:
Splign:
1.39.8"exon679..805/gene="Prkacb"/gene_synonym="Pkacb"/inference="alignment:
Splign:
1.39.8"
quenceTaggedSite,(STS)序列位置标签:
一段短的DNA序列(200-500个碱基对),这种序列在染色体上只出现一次,其位置和碱基顺序都是已知的。
在PCR反应中可以检测出STS来,STS适宜于作为人类基因组的一种地标,据此可以判定DNA的方向和特定序列的相对位置。
ETS是cDNA上的STS。
STS765..844
/gene="Prkacb"/gene_synonym="Pkacb"/standard_name="Prkacb"/db_xref="UniSTS:
507858"exon806..901/gene="Prkacb"/gene_synonym="Pkacb"/inference="alignment:
Splign:
1.39.8"exon902..1024/gene="Prkacb"/gene_synonym="Pkacb"/inference="alignment:
Splign:
1.39.8"STS940..1155/gene="Prkacb"/gene_synonym="Pkacb"/standard_name="Prkacb"/db_xref="UniSTS:
144190"exon1025..1189/gene="Prkacb"/gene_synonym="Pkacb"/inference="alignment:
Splign:
1.39.8"STS1043..1249/gene="Prkacb"/gene_synonym="Pkacb"/standard_name="RH133906"/db_xref="UniSTS:
217189"exon1190..4324/gene="Prkacb"/gene_synonym="Pkacb"/inference="alignment:
Splign:
1.39.8"STS1437..2399/gene="Prkacb"/gene_synonym="Pkacb"/standard_name="Prkacb"/db_xref="UniSTS:
507175"STS1437..1602/gene="Prkacb"/gene_synonym="Pkacb"/standard_name="X61434"/db_xref="UniSTS:
125826"ORIGIN
1tttgagttattctggaggtatatgaaggaagctaggatagctagctggggaaaaaaaagc61taaacctcgttacataaaacatctttggcattattctcttatctagtagtacctcctact121gggcatttgggcgttgctttgggggcttttcttttaaaacaaaagagagctcttggtttt181cggctgcctgctccagcgtatgtgtttacaccatcgctgcctccagagattagcataact241ccctttgcagtcgggctgttgttctgagcaatatgctctggagacatt
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- PKAcb