Advanced gastric cancer in different age groups in contrast to the clinical and pathological feature.docx
- 文档编号:5804694
- 上传时间:2023-01-01
- 格式:DOCX
- 页数:4
- 大小:18.13KB
Advanced gastric cancer in different age groups in contrast to the clinical and pathological feature.docx
《Advanced gastric cancer in different age groups in contrast to the clinical and pathological feature.docx》由会员分享,可在线阅读,更多相关《Advanced gastric cancer in different age groups in contrast to the clinical and pathological feature.docx(4页珍藏版)》请在冰豆网上搜索。
Advancedgastriccancerindifferentagegroupsincontrasttotheclinicalandpathologicalfeature
AdvancedgastriccancerindifferentagegroupsincontrasttotheclinicalandpathologicalfeaturesofAnalysis
[Abstract]ObjectiveTostudytheyoungandelderlypatientswithadvancedgastriccancer,endoscopiccharacteristicsandclinicalandpathologicalfeatures.MethodinourhospitalinJanuary2000-200912menstrualsurgeryandpathologicallyconfirmed320casesofadvancedgastriccancer(including45youngand275elderlypatientswithgastriccancer)wereretrospectivelyanalyzedresultsofgastriccancersitecomparison,younggrouptothemajorityoftheantrum,cardiaincreasedtheproportionofelderly,withdiffusegastriccancermorecommoninyoung,mostlypoorpathologicaltypepoorlydifferentiatedtype,highlymalignantandtheyouthgroupⅢb,Ⅳperiodtheproportionoflivermetastasis,peritonealmetastasisratehigherthantheoldergroup,thedifferencewasstatisticallysignificant.Conclusionofadvancedgastriccancerinyounghigh-gradediffusemainly,theincidenceisrising,younghighdegreeofmalignancyofgastriccancer,theprognosisispoor,shouldstrengthentheyouthcancerawarenessandvigilance.
[Keywords]youngpathologicalfeaturesofgastriccancerbiologicalbehavioroftheelderlyGastriccancerisoneofthemostcommonhumanmalignancies,theincidencewassignificantlyhigherthaninAsiaEuropeandAmerica,countrieswithhighratesofgastriccancerinChina.Bothmaleandfemaletopsoftheircancerincidenceandmortalityinthefirsttwo,accountingforgastrointestinalcancerthefirst,peakage50to70yearsold.At35yearsofagegastriccancerforyoungpeople[1].gastriccanceroccurintheelderly,butyounginrecentyearsthetrendofincreasingincidenceofgastriccancer.Article200ofthehospitalinJanuary~December2009treated320casesofadvancedgastriccancerpatientswithasummaryanalysisofclinicaldata,andcompareyoungandoldwithdifferentclinicalcharacteristicsofgastriccancerandpathologicalconditions,provideareferenceforclinicaldiagnosisandtreatment.
Objectandmethod1.1ObjectWeretreatedinhospitaluppergastrointestinalendoscopyandbariummealexaminationandconfirmedbypathologyoropensurgeryforadvancedgastriccancer320cases,45cases≤35yearsofage,foryouthgroups,including18malesand27females,meanage26.5years.275patientsaged>60yearsold,asoldagegroup,male210cases,65females,theoldest79yearsold.patientdatawerederivedfromtheoriginalhospitalmedicalrecordsandfollow-upresults.
1.2diagnosticcriteriaforpathologicalUsingtheWHOclassificationcriteria,dividedintopapillarycarcinoma,tubularcarcinoma,mucinouscarcinomaandsignetringcellcarcinoma,degreeofdifferentiationintohighlydifferentiatedtype(includingtubularwelldifferentiated,moderatelydifferentiatedadenocarcinomaandpapillaryadenocarcinoma)andpoorpoorlydifferentiatedtype(includingpoorlydifferentiatedtubular,undifferentiated,andmucinousadenocarcinoma,signetringcellcarcinoma.
1.3endoscopydiagnosticcriteriaAdvancedgastriccanceraccordingtoBormanntypestandardsaredividedintotypeI(polypoid),Ⅱtype(ulcer-type),Ⅲtype(ulcerinfiltrating),Ⅳtype(diffuseinfiltrative).
1.4MethodsUsingSPSS13statisticalsoftware,usingχ2testforcategoricalvariables.ToP<0.05forthedifferencewassignificant.
2Results2.1ComparingthetumorDiseasesitecanbeseenfromTable1:
agegroup178casesofgastriccardia(64.6%),youthgroup3patients(7.6%),gastricbodyagegroupof57patients(20.9%),youthgroupof12patients(26.7%),stomachsinusagegroup,28patients(10.3%),youthgroupof26patients(75.0%),totalgastrectomyagegroupof6patients(3.2%),youthgroup1patients(3.1%).cardiagastriccancergroupwassignificantlyolderthanyounggroup,andgastriccancerwassignificantlylowerthantheyounggroup(P<0.01).
Table1agegroupandrelativelyyounggroupofgastriccancersite(%Group(n)full-cardiagastricstomachgastricantrumAgegroup(275178(64.6%)57(20.9%)28(10.3%)12(4.2%)
Youth(45)3(7.6%)12(26.7%)26(58.5%)3(7.2%)
2.2gastroscopytypecomparisonBorrmanntypeIcomparedage-groupof51patients(18.4%),youthgroup,4cases(9.5%),Ⅱage-groupof150patients(54.6%),younggroupof8patients(17.8%),Ⅲage-groupof47patients(17.2%),youthgroupof16patients(34.2%),Ⅳage-groupof27patients(9.8%),youthgroupof10patients(38.5%)agegroupⅠandtypeⅡhigherthantherateoftheyounggroup,andⅢ,typeⅣyounggroupthaninthehighrateofelderlypatients,thedifferenceswereverysignificant(P<0.01).
Table2elderlygroupandyounggroupofgastricendoscopytypecomparison(%Group(n)ItypetypetypeⅡⅢⅣtypeAgegroup(27551(18.4%)150(54.6%47(17.2%27(9.8%
Youth(454(9.5%8(17.8%16(34.2%17(38.5%
2.3HistologicalclassificationmoreTable3,poorlydifferentiatedpoorelderlygroupof94patients(34.0%),youthgroup,39patients(85.8%),thetwogroups,P<0.01,inwell-agedgroup153cases(55.8%),youthgroup6patients(14.2%),thetwogroups,P<0.01.
Table3agegroupswiththeyounggroupofgastriccancerhistologicaltypecomparison(%Group(n)well-differentiatedcancer,poorlydifferentiatedcarcinomaofpoorcancerAgegroup(275)28(10.2%)153(55.8%)94(34.0%)
Youth(45)0(06(14.2%)39(85.8%)
2.4TNMstageandmetastasiscomparedTwogroupsofelderlypatientswithTNMstagegroupsⅡ,Ⅲaperiodof187cases(67.9%),Ⅲb,Ⅳperiodof88cases(32.1%),livermetastasisin6cases(2.3%),peritonealmetastasisin23cases(8.5%);YouthTNMstageⅡ,Ⅲaperiodof19cases(36.5%),Ⅲb,Ⅳperiodof27cases(63.5%),livermetastasesin6cases(9.3%),peritonealmetastasisin17patients(25.5%)theyouthgroupⅢb,Ⅳphasewas,livermetastasis,peritonealmetastasiswerehigherthantheoldgroup(P<0.05).Linkstofreediscussionpaperdownload
3
Nearly40years,theyoung5-yearsurvivalofgastriccancerhasnotimprovedsignificantly,therefore,shouldincreasethevigilanceoftheyouthcancer,strengthenthestomachoutsidetheperformanceandthetransferofknowledgeofsymptoms,importanceofearlydiagnosisofsuspectedcasesshouldbeactivelypursuedthestomachmicroscopyandpathologytrack.endoscopiccharacteristicsofyounggastriccancerwiththepredilectionsitesofdifferentageinthisgroupofmiddle-agedgroupantrumcanceraged28cases(10.3%),youthgroupof26patients(75.0%),cardia178casesofgastricagegroup(64.6%),youthgroup3patients(7.6%),gastricbodyoldagegroup,57patients(20.9%),youthgroupof12patients(26.7%),thewholestomachagegroupof6patients(3.2%),youthgroup1patients(3.1%)agegroupatthebottomofgastriccardiacancerincidenceintheyouthgroupandyouthgroupofgastriccancerincidenceintheelderlygroup.occurinthegastricantrumwiththeliteraturesimilar.Thispredilectionsitesofdifferentreasonsarenotclearfromthehistologicalview,thehumangastricepithelialdegenerationandintestinalmetaplasiaincreasedwithage,withcardiagastricantrumtothedirectionofthetrend,butwithage,theoccurrenceofinthegastriccardiapartoftheincreaseintheproportionofpatients.esophagealsmoothmuscledegenerationduetotheelderly,lowloweresophagealsphincter,andpronetonervousdisordersregulatorymechanisms,leadingtostomachanesophagealreflux,recurrentinflammatorydamagecausedbycardiacregion,repair,hyperplasia,andfinallytheformationofcancer[2].
Thedataalsoshowthatthepathologicaldegreeofdifferentiationandgeneralclassificationtwodifferentagegroupstherearesignificantdifferences,withincreasingage,theproportionofwell-differentiatedtypeofgastriccancerincreasedtheyounggrouptheproportionofpoorlydifferentiatedadenocarcinomathantheoldergroup,whiledifferentiatedadenocarcinomawithlessthantheoldergroup,suggestingthatwithage,thebetterthedegreeofdifferentiationgraduallyincreasedtheproportionofcancer,indicatingahighdegreeofmalignancyofgastriccancerinyoungpeople,invasiveability,andearlytransfer,theelderly,gastriccancerweak,relativelylatetransfersbecauseofpooryoungpeopleingastriccancercelldifferentiation,biologicalbehaviorthantheevil,diffusegrowth,easytoinfiltratemuscularisandserosa,sothelargelesionsmorecommoninelderlygastriccancercellsarerelativelygood,moderategrowth,mostlylumpygrowth,itisrelativelysmalllesionsfromthisgroupofpatientstoseeyoungpeoplewithcancerhistologicaltypeofpoorlydifferentiatedadenocarcinoma,mucinouscarcinoma,signetringcellcarcinomaandundifferentiatedcarcinomamorecommon,Andthesetypesoftumorshaveahighdegreeofmalignancy,whichalsodeterminestheyoungcancerdiseaseprogression,pronetoearlymetastasis,poorprognosis,theyouthgroupofwell-differentiatedadenocarcinoma,andfarlessthanintheoldergroup,butthediffusetypegastriccancerissignificantlymorethantheoldergroup,particularlyundifferentiatedcarcinomaandsignetringcellcarcinoma,suggestingthatthesetwopatientswithgastriccancerinyoungpeopleplaysanimportantrole,suggestingthattheincidenceofgastriccancerwithage,genderarerelated[3].
Thedatashow:
theyounggrouptoinvasiveulcerativeformofgastriccancer,diffuseinfiltratingtype,accountingforabout72.7%inelderlygroupofpolypsandulcerativeaccounted73%,BorrmannⅡ,Ⅲ,Ⅳmainlytothedeepinfiltration,caneasilypenetratethemusclelayerdipmadeserosa,withearly
- 配套讲稿:
如PPT文件的首页显示word图标,表示该PPT已包含配套word讲稿。双击word图标可打开word文档。
- 特殊限制:
部分文档作品中含有的国旗、国徽等图片,仅作为作品整体效果示例展示,禁止商用。设计者仅对作品中独创性部分享有著作权。
- 关 键 词:
- Advanced gastric cancer in different age groups contrast to the clinical and pathological feature
![提示](https://static.bdocx.com/images/bang_tan.gif)
链接地址:https://www.bdocx.com/doc/5804694.html