实验2PubMed 的使用Word格式文档下载.docx
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实验2PubMed 的使用Word格式文档下载.docx
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Creutzfeldt-Jakob6484
Gaucher4671
Leeukaemia240634
Breastcancer237638
2Perfomthesamesearch,onlyforarticleswhichappearedexactlyduringthepastyear.PrinttheAbstractsofthefirst5searchresults,sortedbyAuthor.
①ⅰCreutzfeldt-Jakob
ⅰ、Creutzfeldt-Jakobdiseaseaffectingthemaxillofacialregion:
acasereport.
Abdel-GalilK,WilliamsC,ChambersP.
Source
BradfordTeachingHospitalsNHSFoundationTrust,St.Luke'
sHospital,Bradford,UnitedKingdom.khalidabdelgalil@doctors.org.uk
Abstract
Creutzfeldt-Jakobdisease(CJD)isararedisordercausedbyprionsthatcanaffectanypartofthecentralnervoussystem.Itischaracterisedbyaninitialnon-specificillnessofvaryingduration,followedbyprogressiveneurologicaldecline.WereportapatientwithsporadicCJDwhopresentedwithneurologicalsymptomsandbilateraldislocationofthetemporomandibularjoints(TMJs).ToourknowledgethisisthefirstreportofsporadicCJDthatinvolvedthemaxillofacialregion.
2009TheBritishAssociationofOralandMaxillofacialSurgeons.PublishedbyElsevierLtd.Allrightsreserved.
ⅱ、Understandingamyloidaggregationbystatisticalanalysisofatomicforcemicroscopyimages.
AdamcikJ,JungJM,FlakowskiJ,DeLosRiosP,DietlerG,MezzengaR.
LaboratoiredePhysiquedelaMatiè
reVivante,EcolePolytechniqueFé
dé
raledeLausanne(EPFL),CH-1015Lausanne,Switzerland.
Theaggregationofproteinsiscentraltomanyaspectsofdailylife,includingfoodprocessing,bloodcoagulation,eyecataractformationdiseaseandprion-relatedneurodegenerativeinfections.However,thephysicalmechanismsresponsibleforamyloidosis-theirreversiblefibrilformationofvariousproteinsthatislinkedtodisorderssuchasAlzheimer'
s,Creutzfeldt-JakobandHuntington'
sdiseases-havenotyetbeenfullyelucidated.Here,weshowthatdifferentstagesofamyloidaggregationcanbeexaminedbyperformingastatisticalpolymerphysicsanalysisofsingle-moleculeatomicforcemicroscopyimagesofheat-denaturedbeta-lactoglobulinfibrils.Theatomicforcemicroscopyanalysis,supportedbytheoreticalarguments,revealsthatthefibrilshaveamultistrandedhelicalshapewithtwistedribbon-likestructures.Ourresultsalsoindicateapossiblegeneralmodelforamyloidfibrilassemblyandillustratethepotentialofthisapproachforinvestigatingfibrillarsystems.
ⅲ、Diagnosticpitfallsinapatientwithposttraumaticexaggeratedstartleresponseandmutisticstupor.
AgorastosA,MuhtzC,KellnerM.
ⅳ、RefractorynonconvulsivestatusepilepticusinCreutzfeldt-Jakobdisease.
AiguabellaM,FalipM,VecianaM,BrunaJ,Palasí
A,CorralL,HerreroJI,BoludaS,MoraJ,IranzoA,SerranoC.
NeurologyDepartment,HospitaldeBellvitge,HospitaletdeLlobregat,Barcelona,Spain.37785mam@comb.cat
Creutzfeldt-Jakobdisease(CJD)isararehumantransmissiblespongiformsubacuteencephalopathy.ThemostcommonclinicalmanifestationsofCJDincluderapidlyprogressivedementia,behaviouralchanges,cerebellardysfunctionandmyoclonus.Otherseizuretypesarerareandnonconvulsivestatusepilepticus(SE)isexceptional.Wereportacaseofa44-year-oldmanwhopresentedapsychoticepisodefollowedbyakineticmutismandrefractorynonconvulsiveSE.ThefinaldiagnosiswasCJD.Continuousvideo-EEGmonitoringrevealedtheictalpatternofnonconvulsiveSEtobeperiodicsharpwavecomplexescharacteristicofCJD.[Publishedwithvideosequences].
ⅴ、[RareformofCreutzfeldt-Jakobdisease].
Al-HamdanyS,HolmIE.
PatologiskInstitut,Å
rhusUniversitetshospital,AalborgSygehus,9000Aalborg,Denmark.
Creutzfeldt-Jakobdisease(CJD)isthemostcommontypeofpriondisease.Aconsiderablevariationindiseasephenotypeisseen,primarilyinfluencedbyanaturallyoccurringpolymorphismintheprionproteingene.WepresentacaseofsporadicCJDofatactictype.MoleculargeneticanalysisshowedaVVpolymorphismatcodon129intheprionproteingene.Thevariouspolymorphismsatcodon129andtheirinfluenceontheclinicalpictureandpathologyarebrieflydiscussed.
②Gaucher
ⅰ、Velaglucerase(Vpriv)forGaucher'
sdisease.
[Noauthorslisted]
ⅱ、Inbrief:
Velaglucerase(Vpriv)forGaucher'
ⅲ、InfectiouscrystallinekeratopathycausedbyStreptococcusAbiotrophiadefectiva.
AbryF,SauerA,RiegelP,SalehM,GaucherD,Speeg-SchatzC,BourcierT.
DepartmentofOphthalmology,UniversityHospitalofStrasbourg,Strasbourg,France.florence.abry@chru-strasbourg.fr
PURPOSE:
ToreportthefirstcaseofStreptococcusAbiotrophiadefectiva-associatedcrystallinekeratopathy.
MET
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