Laparoscopic Myotomy.docx
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Laparoscopic Myotomy.docx
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LaparoscopicMyotomy
AnnSurg.2006May;243(5):
587–593.
LaparoscopicMyotomyforAchalasia:
PredictorsofSuccessfulOutcomeAfter200Cases
AlfonsoTorquati,MD,MSCI,WilliamO.Richards,MD,MichaelD.Holzman,MD,MPH,andKennethW.Sharp,MD
FromtheDepartmentofSurgery,VanderbiltUniversityMedicalCenter,Nashville,TN.
Objective:
Laparoscopicmyotomyisthepreferredtreatmentofachalasia.Ourobjectivesweretoassessthelong-termoutcomeofesophagealmyotomyandtoidentifypreoperativefactorsinfluencingtheoutcome.
Methods:
Preoperativeandlong-termoutcomedatawerecollectedfrompatientsundergoinglaparoscopicmyotomyforachalasiaatourinstitution.Theprimaryendpointofthestudywasthepostoperativechange(delta)indysphagiascore.Thisscorewascalculatedbycombiningthefrequencyandtheseverityofdysphagia.Persistentpostoperativedysphagiawasdefinedas1standarddeviationlessthanthemeandeltascoreofallpatients.Logisticregressionwasusedtoidentifyindependentpreoperativefactorsassociatedwithsuccessfulmyotomy.
Results:
Atotalof200consecutivepatientswereincludedinthestudy.Atameanfollow-upof42.1months,themeandeltadysphagiascorewas7.1±2.6;therefore,themyotomywasconsideredsuccessfulwhenthedeltascorewas>4.5.Accordingtothisdefinition,170(85%)patientsachievedexcellentdysphagiarelief(responders).Respondershadhigherpreoperativelowesophagealsphincter(LES)pressurethannonresponders:
42.6±13.1versus23.8±7.0mmHg(P=0.001).HighpreoperativeLESpressureremainedanindependentpredictorofexcellentresponseinthemultivariatelogisticregressionmodel.PatientswithLESpressure>35mmHghadanoddsratioof21.3,makingmorelikelytoachieveexcellentdysphagiareliefaftermyotomycomparedwiththosewithLESpressure≤35mmHg(oddsratio,21.3;95%confidenceinterval,6.1–73.5,P=0.0001).
Conclusion:
Laparoscopicmyotomycandurablyrelievesymptomsofdysphagia.ElevatedpreoperativeLESpressurerepresentsthestrongestpositiveoutcomepredictor.
InNorthAmerica,esophagealachalasiaisarareidiopathicmotilitydisorderthataffects1in100,000individuals;yetitisthemostcommonlydiagnosedprimaryesophagealmotilitydisorder,andsecondonlytogastroesophagealrefluxdisease(GERD)asthemostcommonfunctionalesophagealdisorder.1Thewidespreadavailabilityofpneumaticdilation,botulinumtoxininjectionsandminimallyinvasivesurgicaltechniquesformyotomyhasresultedincontentioustherapeuticstrategies.Ingeneral,alltreatmentsarefocusedonthereductionofloweresophagealsphincter(LES)restingpressure,resultinginimprovedesophagealemptyingandsymptomaticreliefofdysphagia.Whilepartiallyandfortheshort-termresponsivetoendoscopicdilatationorbotulinumtoxininjections,mostpatientswithachalasiaeventuallyrequireoperativemanagementbecauseonlysurgicaltreatmenthasbeenproventoprovidelong-termreliefofdysphagia.2
Surgicaltreatmentofachalasiahasevolveddramaticallyoverthepast13years.SincethefirstreportoflaparoscopicHellermyotomyin1991byCuschieri3andthoracoscopicHellermyotomybyPellegrini4in1992,minimallyinvasivesurgeryhasbecamethegoldstandardforthetreatmentofachalasia.Morerecently,thelaparoscopicmanagementofesophagealachalasiahasachievedwidespreadacceptanceandisnowthefirstlineoftherapyforpatientswithachalasia.2Thesatisfactoryshort-termresultsofthisprocedurearewelldocumentedinseverallargeseries.5–11Inthesestudies,persistentpostoperativedysphagiawasobservedin10%to30%ofthepatients,andlittleisknownaboutthepreoperativefactorsthatmaypredictlong-termresolutionofdysphagiaafterlaparoscopicesophagealmyotomy.Therefore,theaimofthisstudywastoidentifypreoperativepatientcharacteristics,includingmanometricandclinicalfindings,thatpredictlong-termsuccessfuloutcomeafterlaparoscopicesophagealmyotomy.
Patients
Thestudy,followingInstitutionalReviewBoard(IRB)approval,wasconductedatVanderbiltUniversityMedicalCenterinNashville,Tennessee.Preoperativedata,includingastructureddysphagiascore,wereprospectivelycollectedonpatientsundergoinglaparoscopicmyotomyforachalasiaatourinstitution.12Allpatientsunderwentpreoperativemanometry.Patientsweretestedwhileoffallantisecretoryorpromotilitymedications.Standardesophagealmanometrywasperformedusinga6-channelsolid-stateprobe(SandhillScientific,HighlandsRanch,CO)withapull-throughtechnique.TheLESpressurewasdefinedasthedifferencebetweentheendexpiratorygastricbaselinepressureandthemiddleend-expiratorypressurejustdistaltotherespiratoryinversionpoint.ClinicaldiagnosisofachalasiawasconfirmedmanometricallybythepresenceofsimultaneousesophagealbodycontractionsandanonrelaxingLES.Inthefewpatientswhounderwentpreoperativemanometryoutsideofourfacility,manometricdatawerereanalyzed.
Allthepatients(n=224)enteredinourachalasiadatabasefrom1994to2004weremailedafollow-upstructureddysphagiascorequestionnaireoraskedtocompleteoneduringafollow-upvisit.Thepatientswhodidnotreturnthequestionnaireswereallowedtoanswerthesurveyoverthephone.Attheend,24patientswereexcludedfromthestudybecausewewereunabletoobtainapostoperativedysphagiascorefromthem.
SurgicalTechnique
OurtechniqueforlaparoscopicHellermyotomyhasbeenpreviouslydescribedindetail.10Briefly,afterthephrenoesophagealligamentisdividedandthefatpadexcisedexposingtheanteriorgastroesophagealjunction,themyotomyisperformedbyincisingthedistal4to6cmofesophagealmusculature.Themyotomyisextended1to2cmontothegastriccardiausingcauteryscissorsoranultrasonicscalpel.Intraoperativeendoscopyisperformedsimultaneouslytoassesstheadequacyofthemyotomy,togaugehowfartocarrythemyotomyontothegastriccardia,andtodetectmucosalperforations.WeaddedaDoranteriorhemifundoplicationinselectedpatientsearlyinourexperience,thosehavingintraoperativeperforation,andmoreroutinelyinourmostrecentexperience.Inourearlyexperience,weroutinelyperformedacontrastswallowonpostoperativedayoneinallpatientstoruleoutanoccultleak.Wecurrentlydoitselectivelyforpatientswhohadintraoperativeperforation,andthosewhohavepostoperativechestpain,tachycardia,orfever.Forpatientsnotrequiringswallowstudy,andthosewithanegativeone,aclearliquiddietisstartedthemorningaftersurgery,andpatientsaredischargedlaterthatday.
OutcomeMeasures
Theprimaryend-pointwaspostoperativechange(delta)indysphagiascore.12Thescore(range0–10)wascalculatedbycombiningthefrequencyofdysphagia(0=never,1=<1day/wk,2=1day/wk,3=2–3days/wk,4=4–6days/wk,5=daily)withtheseverity(0=none,1=verymild,2=mild,3=moderate,4=moderatelysevere,5=severe).Thecutoffpointusedtodichotomizetheoutcomeafterlaparoscopicesophagealmyotomywasselectedatonestandarddeviationbelowthemeandeltascoreoftheentirecohort.Patientwithdeltadysphagiascorefallingbelowthecutoffpointwereconsideredwithunsuccessfuloutcomegroup.Patientswhounderwentendoscopicdilationand/orredomyotomy,aftertheinitialmyotomy,werealsoclassifiedintothisgroup.
StatisticalAnalysis
Thedataarepresentedasmean±SDforcontinuousvariables,andascountsorproportions(%)forcategoricalvariables.Correlationswereanalyzedbyunivariateregressionanalysis(Pearson)andSpearmancorrelationcoefficients.
Binarylogisticregressionanalysiswasusedinbothunivariateandmultivariatemodelingtoidentifyindependentpreoperativevariablesassociatedwithlong-termreliefofdysphagiaafterHellermyotomy.Independentvariablesexaminedincluded6putativepreoperativefactors:
age,gender,LESpressure,historyofendoscopicdilation,historyofbotulinumtoxininjection,andASAclass.Thefollowingmodel-buildingstrategywasused.Univariateanalysisusinglogisticregressionwasappliedtoidentifysignificantassociationswiththedependentvariable(surgicaloutcome).Transformedanduntransformeddatawereusedintheanalysis.AllindependentvariableswithassociationsofP≤0.1thenunderwentmultivariateanalysisbysimplyenteringthemtogetherusingthebackwardstepwisemethod.Thefollowingcutoffpointswereusedforthebinarylogisticregressionstepwisemethods:
P=0.05forentryintothemodelandP=0.10forremovalfromthemodel.The“best”modelforeachcasedefinitionwasbasedonthestrengthofthemodel(HosmerandLemeshowgoodness-of-fittest),itsclinicalutility,andthebiologicplausibilityofthemodel.Allcontinuousvariablesincludedinthefinalmodelwerethencategorizedtoimproveeaseofuse.Modelparameterswereestimatedbythemaximum-likelihoodmethod.Fromtheseestimates,oddsratios(OR)with95%confidenceintervals(CI)werecomputed.
TheSPSSstatisticalsoftwareprogram(version13.0,SPSS,Chicago,IL)wasusedforallanalyses.StatisticalsignificancewassetatP<0.05.
RESULTS
Follow-updysphagiascoreswereavailablefrom200patients(93females)whounderwentlaparoscopicmyotomyatVanderbiltUniversityMedicalCenter.Patientagesrangedfrom13to80years(49.5±1.5years).Themedianhospitalstaywas1day(range,1–3days)Therewere12intraoperativeperforations:
6inthefirst50proceduresand6inthelast150.Alltheesophagealperforationswereidentifiedandrepairedatthetimeofsurgeryandpatientshadnosequelae.Fourconversionstoanopenprocedureoccurredwithinthefirst50patients;therewe
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